GLP-1

Every GLP-1 claim we've checked against the studies, newest first, each graded from Solid to Debunked by the evidence in people.

Three weight-loss pens standing like bars in a chart under the words These 3 work: tirzepatide -21%, semaglutide -15%, liraglutide -8%
Oct 20, 2026 Grade: Solid

Peptides for weight loss: three approved ones cut 8% to 21%

Wegovy, Zepbound and Saxenda cut body weight 8% to 21% in large randomized trials. Retatrutide and research-only vials are not approved.

 A man in his 20s with his hand on his chin looking at three glass vials on a podium, the top one, labeled Tirzepatide, lit in gold
Oct 4, 2026 Grade: Solid

The best peptides in 2026, ranked by human evidence

Tirzepatide took off 20.9% of body weight in 2,539 adults. We ranked 23 peptides by human trials: 6 work for one use, 9 were never tested for theirs.

 A man of about 50 at a kitchen table holding up a small white pill, with a glass of water beside him
Oct 3, 2026 Grade: Promising

Foundayo and the Wegovy pill cut weight 11% to 14% in trials

In trials, the daily pills Foundayo (orforglipron) and the Wegovy pill cut weight 11% to 14%. People who switched from a shot to the pill kept most of their loss.

 A surprised woman in her 30s next to a purple injector pen lying on a white bathroom scale
Oct 1, 2026 Grade: Promising

Retatrutide cut body weight by a quarter in its big trial

In a 2,339-person trial, retatrutide's top dose cut weight by 25% on average, or 28% for those who stayed on it. It hasn't been tested head to head with tirzepatide.

 A skeptical man in his 20s with his arms crossed, next to four glass vials labeled BPC-157, TB-500, Epitalon and MOTS-c and one blue injector pen under a spotlight
Sep 29, 2026 Grade: Unproven

BPC-157 isn't the next Ozempic

GLP-1 peptides cut weight 15% to 28% in big trials. BPC-157 sped healing in rats, but only 31 people have tried it, none against a placebo.

 A man in his 30s looking at his flexed arm, with a blue injector pen lying on the table in front of him
Sep 27, 2026 Grade: Debunked

Muscle loss on Ozempic matches any other diet

The claim that 40% of GLP-1 weight loss is muscle mixes up muscle with lean mass. Trial scans show the drugs cost about as much muscle as any weight loss.